Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, we investigated the molecular design of tumor-directed trifunctional antibody-cytokine fusion pro
BackgroundHepatitis C virus (HCV) has been reported to regulate cellular microRNAs (miRNAs).The HCV core protein is considered to be a potential oncoprotein in HCV-related hepatocellular carcinoma (HCV-HCC), but HCV core-regulated miRNAs are largely unknown.Our preliminary experiments revealed significant jacques marie mage baudelaire 2 down-regula
Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.SMC-containing condensin complexes create chromosome topologies essential for mitosis/meiosis, gene expression, recombination, and repair.Many eukaryotes have two condensin complexes (I and II); C.elegans h
Being situated on the major subduction zones in conjunction with a considerable number of submarine active faults and lilac charger plates coastal volcanoes, Japan has a long history of catastrophic tsunami events.Consequently, enormous efforts in disaster mitigation, particularly in relation with tsunami hazards, have been made across the country.